• Grapefruit
  • Grapefruit

Grapefruit

  • Scientific Name
    Citrus paradisi
  • Family
    Rutaceae
  • Origin
    Israel, US, Argentina, South Africaetc.

Plant description

Grapefruit belongs to the Rutaceae family and grows up to 12 meters. Its leaves are dark green, oval, and arranged alternately, while the plant bears fragrant, cream-colored flowers. The fruit, after which it is named, grows in clusters similar to grapes. Grapefruits are typically yellow in color, combining sweetness and tartness with a slight bitterness. Varieties include white-fleshed, light red-fleshed, and red-fleshed, as well as nucleate and non-nucleate types. Among these, the colored non-nucleate variety is favored for fresh consumption, whereas the white-fleshed non-nucleate variety is preferred for processing.
Historically, Grapefruit cultivation is believed to have originated in the 18th century on the island of Barbados in the West Indies. The cultivation expanded to Florida in the United States around 1823, and commercial production thrived in Florida by 1930. In the United States, Grapefruit is a popular fruit and serves as the largest supplier of grapefruit oil.

Essential oil composition

Grapefruit (cold-pressed)
  • Grapefruit (cold-pressed)

  • INCI
    CITRUS GRANDIS (GRAPEFRUIT) PEEL OIL
  • Parts of Plant Used
    Peel
  • Extraction Method
    Cold Press
  • Extraction Rate
    0.06% - 0.1%
  • Notes
    Top
  • Aroma Family
    Citrus

Grapefruit (cold-pressed) Essential Oil Properties & Uses

About 0.06%-0.1% of Grapefruit essential oil is obtained from its peel by Cold Press, resulting in a yellow to slightly reddish colored oil. Unlike Orange and Lemon oils, Grapefruit oil is obtained in smaller quantities. Its primary component is nootkatone, along with characteristic citrus elements like limonene and myrcene.
Its aroma carries a mild bitterness attributed to nootkatone. It also possesses the refreshing acidity characteristic of citrus fruits, creating a revitalizing fragrance with a notable freshness. The oil is a well-balanced combination of sweetness and bitterness, making it an excellent choice when seeking to refresh or detoxify the mind. This distinctive quality can be blended with spicy scents for use in men's and unisex products, or combined with other citrus essential oils to enhance the overall freshness. Due to its relatively mild fragrance, it is advisable to add a bit more of this essential oil to maintain a well-balanced aroma blend.

Essential oil composition

Essential oil composition

※An example of one batch production is shown here.

  • Limonene 94.34%
  • Myrcene 2.25%
  • Nootkatone 0.10%
  • Other components 3.31%

Functions and Efficacies

Limonene

Limonene
  • IUPAC Name
    1-methyl-4-prop-1-en-2-ylcyclohexene
  • Molecular Formula
    C10H16
  • Molecular Weight
    136.23 g/mol
  • CAS No.
    138-86-3
  • Structure
    Monocyclic monoterpene

Functions and Efficacies of Limonene

in slico in vitro ex vivo in vivo
Non-clinical Clinical
Mice Rats Guinea Pigs Insects Rabbits Human
Stress Reduction
Memory Improvement
Anti-cancer Effects

Stress Reduction

A study reported that mice subjected to cold stress at 4°C (41°F) exhibited reduced elevations in blood corticosterone levels when treated with limonene. Furthermore, the same report demonstrated that limonene effectively lowered corticosterone levels in the blood of mice exposed to both physical and mental stress.1)

Memory Improvement

A study reported that when acetylcholinesterase reacts with acetylthiocholine in phosphate-buffered saline, the introduction of limonene inhibits the degradation by acetylcholinesterase. Acetylcholinesterase plays a role in the breakdown of acetylcholine, a hormone associated with memory and learning. In the same report, it was also noted that limonene suppressed memory impairment induced by scopolamine administration in rats.2)

Anti-cancer Effects

A report indicated that the consumption of limonene by breast cancer patients resulted in reduced expression of Cyclin D1, a protein crucial for cell division, within tumors.3)Furthermore, numerous other studies have also documented the anticancer properties of limonene.4)5)

  • 1)Fukumoto et al., Stress and Health, 2008
  • 2)Zhou et al., Nutritional Neuroscience,, 2013
  • 3)Miller et al., Cancer Prevntion Research, 2013
  • 4)Ajikumaran Nair S et al., Phytomedicine, 2018
  • 5)Chaudhary et al., Human & Experimental Toxicology, 2012

IFRA

Grapefruit:
There are restrictions on its use in the final product due to the possibility of phototoxicity caused by the presence of furocoumarins (bergapten).

Grapefruit

※Only information for selected components are shown here.

Limonene:
Oxidized limonene can cause dermal sensitization. For essential oils with a high limonene content, it is advisable to use only when the level of peroxides is maintained at a minimum (20 mol/l) through the incorporation of antioxidants.

※Only information for selected components are shown here.

References
Jennie Harding [Handbook of Essential Oil and Plant Oil] Tokyo-do Publishing, 2010.
Shinichiro Otsuki/Yukiko Ozaki [Scientific Name Etymology Dictionary of Herbs] Tokyo-do Publishing, 2009.
Jennie Harding [Illustrated Reference Book of Herbs] Sancho Publishing, 2012.
Freddy Ghozland/Xavier Fernandez [L’Herbier Parfume] Hara Publishing, 2013.
Kyohei Mikami [Comprehensive Guide to Essential Oils] Fragrance Journal, 2010.
Yuzuru Ogura [Dictionary of Plants] Tokyo-do Publishing, 1957.
Nobuo Ohashi [Dictionary of Medical Herbs] Tokyo-do Publishing, 2016.
Wanda Sellar [The directory of essential oils] Fragrance Journal, 1992.
Aroma Environment Association of Japan [AEAJ Aromatherapy Certification Official Textbook grade1&2] Sekaibunka, 1999.
Robert Tissearand [Essential Oil Safety] Fragrance Journal, 2018.
Ayako Berg [Aromatherapy Essential Oil Dictionary] Seibido Shuppan, 2022.
Azusa Annells [Enjoying Fragrance: An Illustrated Book of Aromas with Characteristics]Natsumesha CO.,LTD., 2023
International Fragrance Association, Grapefruit oil expressed, 2020.
International Fragrance Association, Limonene, 1995.
(All written in or translated to Japanese.)
Supervisor
Yamamoto Perfumery co., ltd.